Cephalexin vs Amoxicillin – What You Need to Know

When comparing Cephalexin vs Amoxicillin, two of the most frequently prescribed oral antibiotics for everyday bacterial infections, it's useful to break down the basics. Cephalexin is a first‑generation cephalosporin that works by disrupting bacterial cell wall synthesis, while Amoxicillin belongs to the penicillin family and blocks bacterial growth by inhibiting cell wall formation. This comparison encompasses spectrum of activity, typical infection targets, and common side‑effects. Knowing the drug class helps you anticipate resistance patterns – Cephalexin often faces resistance from beta‑lactamase‑producing Staphylococcus, whereas Amoxicillin can be knocked out by similar enzymes unless combined with a clavulanic acid booster.

Key Differences in Use, Dosing, and Safety

Both antibiotics treat skin, ear, respiratory, and urinary tract infections, but the details matter. Cephalexin is typically dosed 250‑500 mg every 6‑8 hours for 7‑10 days, making it a solid choice for uncomplicated skin infections and bone infections where a cephalosporin shines. Amoxicillin is usually taken 500 mg three times daily, or 875 mg twice daily for more severe infections. The dosing schedule influences patient compliance – fewer pills per day can boost adherence, especially in children. Safety profiles overlap (nausea, diarrhea, rash), but amoxicillin carries a slightly higher risk of allergic reactions in penicillin‑sensitive individuals. Kidney function also guides the choice; cephalexin is cleared mainly by the kidneys, so dose adjustments are crucial in renal impairment, while amoxicillin can be used with a bit more flexibility.

Understanding how these drugs interact with other meds is part of the picture. Cephalexin may reduce the effectiveness of oral contraceptives, and amoxicillin can interfere with the absorption of certain iron supplements. When you factor in cost, generic cephalexin often undercuts amoxicillin, but insurance formularies vary. The bottom line is that the right pick depends on the infection type, patient history, and practical concerns like dosing frequency and price. Below you’ll find a curated set of articles that dive deeper into each antibiotic’s mechanism, side‑effects, real‑world usage tips, and how to spot when one might be a better fit than the other.